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The goal of dose-finding studies is to find the highest tolerable dosage: the maximum tolerated dose (MTD) that corresponds to some given acceptable toxicity rate.
HIGH FH: not adequately controlled defined as an LDL-C ≥160 mg/dL at the screening visit bMaximally-tolerated statin dose defined as: the highest tolerable registered dose of daily statin currently administered to the patient, that is rosuvastatin 20 mg or 40 mg daily; atorvastatin 40 mg or 80 mg daily; simvastatin 80 mg daily (if already on this dose for >1 year).
Patients who do not tolerate up-titration to 1.8 mg liraglutide will remain on the highest tolerable dose of liraglutide.
This study will also determine the highest tolerable dose that can be given and whether it causes your cancer to shrink or remain stable.
For years, we have read in newspapers as two degrees of warming was invoked as the highest tolerable level, beyond which disaster would ensue.
The highest tolerable level of the measurement system variability (σm) is firstly assessed by means of PTR∗ in the quarter of plane (Tol, σm).
Similar(23)
There is an imperative need for new Dac formulations that could extend the drug half-life in vivo while also achieving higher tolerable dose.
The 100 μg dose is an extremely high tolerable dose compared with similar drugs.
Active targeting can minimize negative side effects in healthy tissues and allow for a higher tolerable dosage of drug.
Better technology and the use of conformal treatment have led to higher tolerable radiation doses (Yang et al, 2005).
For those in end-of-life care, antidiabetic medications are aimed at avoiding symptomatic hyperglycemia with higher tolerable glycemic levels.
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