Additionally, the level of DPP-IV inhibitory activity for that peptide was the highest among all the tested peptides.
Two patients (#55307 and #55308) each only responded against one of the tested peptides, while the highest number of responses was found using PBMC from patient #55410: Here, responses against seven different epitopes were detected.
Additionally, this tetrameric peptide showed the highest specificity towards tumorigenic cells among the tested peptides.
No effect on cell viability and proliferation was detected with MTT for the tested peptides even at the highest concentration applied (Additional file 3: Figure S3).
As shown in Fig. 4a, all four tested peptides dose-dependently bound to LPS, with (KW 5 exhibiting the highest affinity.
All three tested peptides had predominant renal clearance.
Four peptides showed no toxicity towards zebrafish embryos at the highest concentration tested (25 μM; ∼64 μg/ml) and one peptide was highly toxic, killing 4-hour-post-fertilization (hpf) embryos immediately after exposure to 1 μM peptide.
The peptide was not cytotoxic to keratocytes up to the highest test concentration of 1 mg/mL.
"Does it mean the highest test score?
