Sentence examples for highest safe dose from inspiring English sources

Among the 102 patients in the trial, 60% of those who got the highest safe dose avoided severe disability, compared with 22% of those who got a placebo.

The highest safe dose of each compound showing efficacy in the tail suspension test was chosen for use in the open field test.

RAC = Recombinant DNA Advisory Committee; TBD, to be determined – the highest safe dose, as determined from cohorts 1 to 3; TNFR Fc = tumor necrosis factor receptor:Fc domain of immunoglobulin fusion protein.

The primary objective of the study was to define the highest safe dose of intermittent infusional 5-FU out of the two given doses in combination with cetuximab and irinotecan for the first-line therapy of mCRC, based on DLTs and adverse events.

To calculate the highest safe oral dose of a noncarcinogenic chemical, regulators must first estimate the point-of-departure (POD) dose that is, the dose below which the chemical does not increase disease risk.

Further treatment with radiotherapy, chemotherapy, and/or retreatment with verteporfin PDT (at the highest safe evaluated dose) was at the discretion of their oncologist and the investigators.

Though the children's waterborne manganese intake was lower than the highest safe daily dose (6 milligrams per day) estimated by the U.S. Institute of Medicine, the authors write that additional dietary exposure could have pushed the total daily dose above this value.

Consequently a high and safe dose should be given.

On the basis of our inability to optimise SEPP1 during the course of the trial, we would recommend a higher, though safe, dose of Se-enriched yeast, i.e. 100 μg/d.

Low RS means that higher but safe doses are needed to control the cancer.

Although the risk of damage is higher with high doses, there is no safe dose for chronic use.