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The three cellulosome-associated ORFs with the highest regulation were the multi-modular xylanases: SIGN-GH11-CBM22-GH10-DOC-CBM22-CE4 (ORF01222), SIGN-GH11-CBM22-DOC-GH11-CE311-CE4 (ORF03896) and significantBM22-DOC-GH11-CE3 (Orelative with rexpressionsignificant relevels expressiof levels of approximately 63, 50, and 25 fold above those of cellobiose-grown cells.
Genes of highest regulation were associated with leukocyte activation (chemokines, chemokine receptors, B- and T-cell genes), endothelial and angiogenic activation, tissue destruction and remodelling [MMP-3, BMP-4, TIMPs].
Rank 1 = highest regulation; bold and underlined = significant regulation relative to the control identified by sign test; bold = identified to be differentially expressed by both tests; italic = identified to be differentially expressed only by F-test; "-" = a rank was not assigned in case the regulation was less than log2-ratio = |0.20|.
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