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Compound 5s exhibited highest potency of all the synthesized compounds.
Structures of the highest potency rocaglates (IC50 values < 10 nM for TRAIL sensitization) and rocaglamide.
Benchmark particles microscale TiO2 and crystalline silica were in the lowest and highest potency groups, respectively.
The compounds MNR4 and MNR5 were found to have highest potency against Plasmodium falciparum in vitro.
The 8c derivative showed the highest potency against cruzain (IC50 = 2.4 μM).
The derivatives containing the bisphenylmethyl pharmacophore (7a c) exhibited highest potency.
The introduction of fentanyl has led to increased competition, and dealers now aim for the best price and the highest potency.
Entinostat exhibits its highest potency against HDAC 1 (nanomolar range) and is less potent against HDACs 2 and 3 (micromolar range).
The racemate rac- u -13c exhibited the highest potency (pIC50 5.67) at and selectivity forac- u -13cGABA uptake assays.
Compound 5i showed highest potency of 12.4 nM against ALK and 24.1 nM against ALK gatekeeper mutation L1196M.
Among the six compounds, compound 8u possessing terminal para-hydroxybenzenesulfonamido moiety and ethylene linker showed the highest potency.
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