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In case of irradiation of medulloblastoma in Ashya, it is necessary to apply the highest possible dose into the former location but protect the tissue around as much as possible.
Interestingly, our preliminary in vivo data suggests that BF102 has no significant toxicity in mice at the highest possible dose we can administered.
Mr. Gelsinger died on Sept. 17, four days after a dose of genetically engineered virus was injected into one of the main arteries of his liver, so as to deliver the highest possible dose of a corrective gene to the cells where it was needed.
Rather, the highest possible dose of CRRT should be initially prescribed to maximize solute clearance.
This was achieved by infecting the fish with the highest possible dose without running the risk of accidentally killing.
The surgeon and radiation oncologist should choose the largest possible suitable applicator in order to ensure that the highest possible dose is delivered to the tumor bed tissue.
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In patients with renal cell carcinoma, several doses of temsirolimus have been tested in clinical trials but toxicity leads to refrainment from using the highest possible dosing.
The specific activity of the peptide should be optimized to achieve the highest possible absorbed dose to the tumour taking both the peptide mass with maximum receptor-mediated uptake and the maximum achievable specific activity into account.
In cancer radiotherapy, knowledge of normal tissue responses and toxicity risks is essential in order to deliver the highest possible absorbed dose to the tumor while maintaining normal tissue exposure at non-critical levels.
The observed improvement in Amax is particularly important since a subpopulation of cancer cells usually resist treatment even at highest possible drug doses.
Inhibitors All inhibitors used in tissue culture were titrated for toxicity (by Sytox stain, AnnexinV stain, PrestoBlue assay) and subsequently used at the highest possible, non-cytotoxic dose.
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