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The highest plasma level was measured in the 6th application week in both animals (553 ng/ml in 5203 and 695 ng/ml in 5204).
In carriers of genotype G/G, we also were unable to demonstrate increased fibrinolysis at 0 and 6 h postoperatively, despite the fact that this genotype displayed the significantly highest plasma level of D-dimer 24 h after surgery.
In the present study, we show that hepatic AMPK is activated by metformin at concentrations higher than 100 μmol/l, i.e. about five times the highest plasma level reported in humans after a single oral drug administration [ 45, 46].
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Plasma from individuals with the highest plasma levels of HSP10 were assayed at least twice in separate assays.
In humans, the highest plasma levels of ibuprofen were seen at 1 hour, the first time sampled, and returned to baseline levels by 8 h (Fig. 5a).
High plasma level of prodrug 26 and significant concentration of active drug 26a were obtained upon oral administration of prodrug 26 in rats.
Surprisingly, the platelet 5-HT content was similar in S and NS but lower in FS with a parallel higher plasma level of 5-HIAA in FS.
High plasma level of LDL-C is a major risk factor for coronary heart disease.
Moreover, biodistribution study indicated higher plasma level for conjugate compared to the free SN38.
Repeated weekly injection of HGF-HVJ liposomes achieves a continuous high plasma level of HGF [ 14- 16].
The persistence of a high plasma level of specific neural enolase or its elevation represents a short-term prognostic factor.
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