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In our study, blood anticoagulated with EDTA, a stronger chelator than citrate, displayed highest plasma concentrations of EVs, supporting the notion that EDTA promotes formation of artefactual microvesicles due to platelet activation30.
ADM, derived from a larger precursor peptide (pro-ADM), is released into the circulation during systemic inflammation, and the highest plasma concentrations are measured in patients with septic shock[1].
The highest plasma concentrations were observed in top predator species (Braune et al. 1999; Muir et al. 1999; Skaare et al. 2000) and in humans with seafood-rich diets (Bjerregaard et al. 2001; Dewailly et al. 1993; Humphrey et al. 2000; Sjodin et al. 2000).
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The highest plasma concentration of BGC20-1531 in our study was detected 75 min after oral administration of BGC20-1531 200 and 400 mg at T0 (Fig. 4).
The administration of exogenous epinephrine with local anesthesia produces the highest plasma concentration in 3 to 6 min and lasts for 20 min [18].
Atropine was expected to reach its highest plasma concentration within two hours after injection [37] and has a four hour half-life [35].
The highest plasma concentration was detected at 8 h and the platinum levels dropped to normal after 4 7 days [ 17].
The highest synovial concentration (1350 ng/ml) was measured simultaneously with the highest plasma concentration in the 6th application week in animal 5211.
In the group with the highest plasma concentration of zeaxanthin (≥0.09 μM), the risk of cataract was reduced by 43 % compared with the control group (<0.04 μM).
Perhaps a counter-regulatory system exists which is more effective in the presence of higher plasma concentrations of duloxetine.
Abnormally high plasma concentrations of amantadine may elicit symptoms of neurotoxicity and cause seizures and coma.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com