Sentence examples for highest number of mutations from inspiring English sources

The gene with the highest number of mutations in 'RetinoGenetics' is 'ABCA4', with 844 mutations, followed by 'RPGR' with 365, 'USH2A' with 347 and 'WFS1' with 127 mutations.

In C3 and C3b, the proximity of the functionally important TED and MG-2 domains accounts for the highest number of mutations.

Hot-spots 960-1175, 1363-1541 and 1848-2574 have the largest number of nucleotides (216, 179 and 727, respectively) amongst the five and are associated with the highest number of mutations causing β-mannosidosis.

Expression levels of PIK3CA, the oncogene bearing the highest number of mutations in breast cancer, were therefore mostly stable in breast cancer subgroups indicating that mutations constituted the main tumor change affecting PIK3CA.

For example, we found that four genes with highest number of mutations in RetinoGenetics are commonly involved in sensory perception of light stimulus, visual perception, sensory perception and visual signal transduction were significantly enriched.

The highest number of mutation-based rerouting to other compartments was for proteins whose wild type form was predicted to localize to the cytoplasm.

Another interesting observation was that while almost all BRCA1/2 mutants exhibit a specific mutational signature, there were also BRCA1/2 wild-type samples with high number of mutations due to this mutational process.

As shown in Table 1 and Figure 3C, while the VH genes amplified from CD19+CD27−IgD+ cells in the control group had a low number of mutations, as expected (average 3 mutations per gene; mutated in 1.2% bp sequenced), the VH genes from patient CD19+CD27−IgD+ cells had a significantly higher number of mutations (20 mutations per gene, P<0.001; mutated in 6.3% bp sequenced).

If one factors in the presence of mutator mutations, or other mechanisms of genetic instability, a proportionately higher number of mutations is obtained.

Classification of somatic variants by nucleotide substitution type showed that HQ-FFPE and FF had similar mutational profiles, while LQ-FFPE samples carried a much higher number of mutations than the FF counterpart, with a significant enrichment of C > T/G > A substitutions.

Moreover, our discovery of the uniquely high number of mutations in this tumor may lend insight into its biological behavior.