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With higher thresholds, the probability in which Straticyte™ and histopathology was the cost-effective option (i.e. the most attractive option) decreased slightly reaching a horizontal asymptote, whereby it offered the highest net benefit in 84% of the simulations (Fig. 2).
This treatment was also observed to have the highest net benefit with acceptable economic return and the highest concentration of post-harvest total N and available soil P with fair levels of other macro- and micro-nutrients.
As indicated in Table 5, the highest net benefit (210, 181.1 Ethiopian birr (ETB) ha−1) was recorded for application of 75% RDF + 11.25 tone ha−1 of vermicompost (T6) followed by application of half the recommended rate of NP fertilizer and 7.5 tone ha−1 vermicompost (T3) (196,289 ETB ha−1).
The highest values for the various growth, yield and quality attributing parameters were recorded for the treatment combination consisting 75% of the recommended rate of NP fertilizer + 11.25 ton ha−1 vermicompost (T6), this treatment was also observed to have the highest net benefit with acceptable economic return as well as a fairly high residual soil nutrient status.
Nonetheless, as per CIMMYT (1988), all the non-dominated treatments resulted in a rate of return above the minimum acceptable value (50 100%), therefore the treatment comprising 75% RDF plus 11.25 ton ha−1 vermicompost (T6) was found to provide the highest net benefit compared to other nutrient integration ratios tested in this study and its MRR is well above the minimum acceptable limit (50 100%).
Cost-benefit analysis determines the intervention with the highest net benefit.
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If costs are found to be less than the benefits then the programme is desirable, and programmes with the highest net benefits are most desirable [4].
The highest net benefits were demonstrated for juvenile offender programmes.
Uncertainty around ICERs is presented as cost-effectiveness acceptability curves, which plot the probability of each of the four treatment regimens having the highest net benefits (ie, being most cost-effective) at a range of ceiling ratios.
This demonstrates that although we can be 98% confident that discontinuous bevacizumab is less costly than continuous bevacizumab, our confidence in the conclusion that discontinuous bevacizumab has the highest net benefits decreases rapidly as the value we place on the small, non-significant QALY gains increases.
RESULTS: In the base-case analysis, all strategies for influenza vaccination had a higher net benefit than the nonvaccination strategies.
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