Sentence examples for highest mutation frequency from inspiring English sources

If we consider the top 100 highest mutation frequency genes as CAN-genes, the average number of the mutated CAN-gene is 29.23 per tumour.

In LATS2, the kinase domain (P = 5.66 × 10−5) and insertion domain (P = 0.03121) had the highest mutation frequency.

To determine the mutation distribution across different domains, analysis through Fisher's exact test shows that both the kinase domain (P = 0.01075) and proline-rich (P = 0.0312) of LATS1 displayed the highest mutation frequency among all the LATS1 domains.

This observation correlates with the highest mutation frequency of hMLH1−/− TGFBR2 cells over time (Fig. 4B).

In the M2 population, the TGFBR2 sequence in the hMLH1−/− background demonstrated the highest mutation frequency (highest at day 21, 240-fold change) over time compared to other different MMR deficient backgrounds as predicted in EGFP histograms (Fig. 3E).

Mutation frequency of the TGFBR2 sequence in the hMSH6−/− background also increased over time and showed the highest mutation frequency on day 35 (14-fold change), although this frequency is much lower than TGFBR2 sequence in hMLH1−/− cells (Fig. 4B).

The highest mutation frequencies were associated with the A8 cMNRs in PTPN13 (22%) and PTPN21 (26%).

The A and D populations had the highest mutation frequencies, followed by the C and B populations.

This high mutation frequency suggests that GNAQ mutational analysis can also be useful in the differential diagnosis of peripherally located melanotic schwannoma with blue nevus.

The high mutation frequency in both familial and sporadic patients makes LRRK2 the most frequently mutated gene of the five major PD genes.

Importantly, the high mutation frequency of the wild-type Cas9 plasmid was not merely due to homologous recombination of the plasmid with the genome.