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Interestingly, compounds 5i, 5j, 5m, and 5n led to significant reductions in the immobility time in the forced swimming test at a dose of 50 mg/kg, and exhibited higher levels of efficacy than the reference standard fluoxetine.
One such antiviral, brincidofovir (BCV, previously CMX001), has demonstrated high levels of efficacy against orthopoxviruses in animal models and is currently under clinical evaluation for prevention and treatment of diseases caused by cytomegaloviruses and adenoviruses.
From the point of view of principles of pain physiology, the high levels of efficacy for the management of dynamic pain represents somewhat an interesting outcome –particularly when compared to the other standards of pain management, such as regional continuous techniques.
This organism has several advantages, including low environmental toxicity due to the high specificity of B. sphaericus toxins, high levels of efficacy and environmental persistence, and the ability to overcome resistance developed against conventional insecticides used worldwide (Nielsen-LeRoux et al. 2001).
All these estimates assume high levels of efficacy and adherence to PrEP.
A further trial was undertaken in the same study site to compare different treatment regimens and high levels of efficacy against episodes of clinical malaria were observed with each treatment regimen [15].
Data from 3 large placebo-controlled clinical studies indicate that relatively high levels of efficacy (ranging from 60% to 90%) are seen in previously unvaccinated young children after a single dose of trivalent LAIV.
Using a carefully stratified and well-parameterized deterministic model of HIV-1 transmission, our analyses suggest that PrEP could have a profound impact on the HIV-1 epidemic, if effectiveness is high (high levels of efficacy and adherence) and usage persists over a decade or more; that is over much of the typical duration of sexual activity of an individual.
With this note of caution, the simulations also support the development of BSV candidates as morbidity and mortality control tools, but imply that these are unlikely to have very substantial effects on transmission, unless they achieve very high levels of efficacy in controlling parasite densities, and/or if deployed via mass vaccination.
Clinical trials of stimulant pharmacotherapy in adults with ADHD indicate high levels of efficacy.
Therefore, it is clear that both agents have demonstrated high levels of efficacy in patients with relapsed/refractory disease.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com