Sentence examples for highest level of mutations from inspiring English sources

In addition, D7S1482 has highest level of mutations among all EMAST markers (five of 18) HNSCC and five of 47 NSCLC, again, mostly by insertion mutations (Xu et al, 2001).

The matrix accumulates the highest level of mutations in the entire open reading frame; by contrast, the N is modified in the carboxyl terminus, and the H has biased hypermutation in a limited region (5, 6 ).

Our study was limited to the hypermutable marker D7S1482, which has one of the highest levels of mutations in upper aerodigestive tract cancers (Ahrendt et al, 2000; Xu et al, 2001) and the addition of newly identified hypermutable markers will increase the number of possible mutant alleles that can be scored.

Similar neoantigen-targeted vaccine approaches were previously tested6,7 in early-phase clinical trials for melanoma, which, unlike glioblastoma, is a type of cancer that has a high level of mutations and neoantigens.

The increased ROS levels also led to more 8OG genomic accumulation, and a higher level of mutations in the DKO cells, suggesting that PQ mutagenesis is mediated primarily by 8OG genomic accumulation.

Analysis of six genes revealed a high level of mutations with a density of about one per 60 kb.

In fibroblasts, complex I deficiency was secondary to a high level of mutations (68%) (Fig. 1 D ).

This observation suggests that the two chosen DNA fragments (hspA and glmM) correspond to domains with a high level of mutations and encode proteins with few functional constraints.

A comparison of consensus sequences of arrayed γ-satellite DNA and small blocks of satellite DNA (140 monomers and less) has shown a higher level of mutations and an absence of conserved CG dinucleotide in last ones.

All of these methods suffer from a relatively high level of mutations in the amplified DNA (error rate 3x10-5[ 3x10-5[ 13]ghly non-uniform andlification due to thighly fidelity and low processivity of the Taq polymerase, respectively.

We next followed the mutation rates of these high-efficiency mutated shoots in all the regenerated transgenic tomato plants with mutations, and found a high level of mutation (30 90%) in T0 plants of both Micro-Tom and Ailsa Craig (Fig. 2a).