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Again, only the highest level of intake showed a significant reduced risk of cancer compared to the reference category (RR 0.40 95% CI 0.14 1.15, p-trend = 0.09).
The HOI is defined as the highest level of intake observed with the available data of acceptable quality, showing an absence of adverse effects.
Two studies from the United States reported no association between dietary secoisolariciresinol and matairesinol and breast cancer, regardless of menopausal status or ER tumour status [ 38, 39], with the exception of reduced risk of ER-negative breast cancer among premenopausal women with the highest level of intake [ 39].
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Nutrient dilution consecutive to high-carbohydrate intakes seems to be a concern only for the very highest levels of intake.
At a high level of intake, yes, and one of these is increased cardiovascular risk.
This high level of intake, particularly compared with other countries, is attributable to the high soil content of selenium in several areas of the United States, which is eventually incorporated in the food chain (Rayman 2008).
Some studies of premalignant lesions and OED have found that risks associated with drinking are dependent upon the level of alcohol intake, with the highest risks observed for the highest level of alcohol intake [ 15, 34, 41].
The concentration of P in faeces ranged from 4 to 23 g kg− 1 of DM corresponding to the lowest and highest level of P intake, respectively.
Therefore, even in the worst case of the highest level of salt intake by diet, the influence of increasingly saline drinking water in the study area due to climate change seems limited at present.
U251 and U87 cells exhibited the highest level of iodine intake after 30 min of iodine exposure.
Furthermore, Nuuk men had the highest smoking year value, the highest n-3/n-6 facid acid ratio and the highest level of seabird intake.
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