Our major focus for this study was therefore to simply document that standard dosing assumptions regarding infliximab may lead to erroneous conclusions regarding its cost, given the high level of escalation seen in this and other studies.
But this particular cruise sets sail on Sept. 9, 2001, so everyone is going to wake up early two days later to a horrible surprise, and the ship's immediate escalation to the highest level of military alert.
If patients received several analgesics on the same day, both the highest and the second highest level of analgesic potency were included in the analyses in order to define escalation categories (eg, a change from level 5 plus level 2 to level 5 plus level 3 indicating that escalation had occurred).
This same model tested in our current trial's design allowed high levels of dose escalation in previous phase I trials for SABR treatment of liver metastases using 3 and 5 fractions.
Apart from routine or near routine encounters, the report identifies "11 serious incidents of a more aggressive or unusually provocative nature, bringing a higher level risk of escalation".
It was predicted that the highest levels of urbanisation and neighbourhood deprivation would be associated with escalation of analgesic treatment to more potent pain medication (eg, tramadol, morphine, methadone, etc).
The comparison of the first and the last prescription of analgesics resulted in the following categories of analgesic escalation: neutral (ie, no change of analgesic potency), escalation in analgesic treatment (ie, change to a higher level of analgesic potency) or de-escalation in pharmacological pain treatment (ie, change to a lower level of analgesic potency) (table 1).
PAGE A12 RAID ON UKRAINE ENERGY COMPANY Security agents raided the offices of Ukraine's state energy company in what appeared to be an escalation of a longstanding power struggle at the highest levels of the Ukrainian government.
