Sentence examples for highest level of activated from inspiring English sources
The most profound phenotypic effects of CIP2A downregulation were observed in BRAF V600E /PTEN null WM9 cells, expressing the highest level of activated AKT.
TXNIP knock-out mice show high levels of accumulated inactive PTEN with higher levels of activated AKT resulting in more glycolytic oxidation in their skeletal muscle [94].
In fact, the actual time course of activation between primary and carcinoma cell lines is remarkably similar, though primary cells maintain higher levels of activated ERK longer following mitogenic stimulation, which would be expected since termination of the signal by MAPK-specific phosphatase MKP1 and MKP2 occurs in the nucleus [18].
HA synoviocytes show higher levels of activated caspase 3 compared to RA synoviocytes.
In addition, significantly higher levels of activated caspase 9 and 3 proteins were detected in the subiculum of CBKOTg mice.
In previous studies, Bcr-Abl+ cells and CML cell lines were shown to have high levels of activated Jak2.
Furthermore, Ku80 heterozygous and null muscles displayed high levels of activated p53 by 2 months of age comparable with 18 months wildtype muscle (Fig 4B).
Furthermore, the actin cytoskeleton in cadherin-11 ΔJMD cells revealed a more extensive cortical F-actin ring that correlated with significantly higher levels of activated Rac1.
We show in two cohorts that patients treated with oxaliplatin have tumors with higher levels of activated pFAK relative to untreated patients or patients administered other neoadjuvant regimens.
Although no difference in the levels of Pyk2 expression was observed in FAK-deficient tumours, Pyk2 is overexpressed in ErbB2 tumours when compared to adjacent mammary tissue that does not express high levels of activated Erbb2.
The WIHS study showed that high levels of activated CD8 T cells are associated with incident AIDS among HCV-viremic women but not HCV-uninfected women, and CD4 activation predicted AIDS in both groups [ 24, 25].
