Compared with meta-analyses of observational studies, those of RCTs are considered to have a higher grade of quality.
Considering the publications' RCT design, the grading commenced at the highest level of quality, lowered by one level for each of the following scientific considerations: risk of bias, consistency of results, directness (generalisability), and precision (sufficient data).
Although only randomized trials are included (i.e. the highest grade) the quality of evidence should be downgraded because in most studies the reporting of adverse events will be imprecise and the probability of reporting bias is presumable.
Among them, only 15 were graded with a high level of quality of evidence, underlying the necessity to continue clinical studies in order to improve the risk-to-benefit ratio of glucose control.
As you may know, the Merriam-Webster dictionary defines me as "of high grade or quality" and also "very large or powerful," and for centuries, that's exactly what I've been.
Different grades have different quality; generally, higher grade means higher quality.
Potable water may be used in chemical synthesis and in early stages of cleaning pharmaceutical manufacturing equipment unless there are specific technical or quality requirements for higher grades of water.
"Given the high-quality assets and despite the overall price, we do see this as a high grading of USAC's [USA Compression's] fleet," they said.
