Sentence examples for highest frequency of mutations from inspiring English sources

The genes with the highest frequency of mutations reported in the literature were chosen.

Melanoma has the highest frequency of mutations of all cancers [17,18].

Microdissected targets histologically classified with dysplasia had the highest frequency of mutations at 17p (TP53), with mutations present in 14/16 888%) HGD targets, 27/39 (69%) LGD targets, and 49/138 (36%) "indefinite for dysplasia" targets.

Activating mutations in the BRAF gene have been identified in many human cancers, with the highest frequency of mutations found in cutaneous melanomas (Brose et al, 2002; Davies et al, 2002; Goydos et al, 2005).

ND6 was the most susceptible coding gene to mutation whilst ND4 had the highest frequency of mutation.

The D-loop harbored the highest frequency of mutation (77.9%) at position 16224 bp in the U87MG cells.

The most common mutations for ofloxacin resistance were in the gyrA gene at codons 94 and 90, the former of which had the highest frequency of mutation (33%).

Mutational screening revealed a high frequency of mutations.

We hypothesise a higher frequency of mutations affecting smokers.

This high frequency of mutations could, however, impede our antibody identification if mutations occurred in PCR primer-binding sites.

We identified a high frequency of mutations in PTEN (50%) and genes involved in the endometrial cancer-related molecular pathway, which involves the IL-7 signaling pathway (PIK3R1, n = 1; AKT2, n = 1; FOXO1, n = 1).