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Inspection of the BSs in this region shows that this group includes those seven genes (out of the 11 marked by solid filled symbols validated by PCR) that had the highest fold induction [37], ranging between 153 and 3.4, whereas the 4 genes that are outside the box had fold changes between 2.6 and 1.6.
Notably, the highest fold induction of FSHβ was greater for the expanded model as compared to the basic model (Figure 4A and Figure 1C), indicating that the pERK5 component in this model boosts levels of FSHβ with decreasing GnRH pulse-frequency.
The highest fold induction (7.4) was observed for receptors with 2 extracellular scaffold linkers, and 6 intracellular linkers on both the PCN (FKBP) and PCC (FRB).
In each of these divergently regulated orthologs, the species with the greatest number of DRE cores within the regulatory region had the highest fold induction suggesting that species-specific regulons have important roles in regulating gene expression.
Following the treatment with LD50 concentrations of DETA/NO, accumulation of nuclear p53 increased with time under both 21 and 0.1% (v/v) O2 relative to untreated controls with the highest fold induction of p53 observed under 0.1% O2.
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Northern blot assay using the common carp (cc) MT-1 cDNA as a probe showed high fold induction of ccMT mRNA levels in the intestine and kidney following exposure to Cd2+ and Zn2+.
However, low-dose infected CD103−/− mice had higher fold induction of Il4, Il5 and Il13 and lower induction of Ifng mRNA in the intestine (Figure 2A).
M3 demonstrated higher fold induction in severe hypoxia/anoxia, relative to mild hypoxia (1% O2) than the SARE.
This correlation of high fold induction with in silico results can be observed for each transcript examined in this study.
In anoxia, the SARE trimer produced significantly (P=0.008) higher fold induction than in 0.5% O2 (Table 2-wrap>).
Induction of specific and / or multiple isoforms of FTs might play roles in higher fold induction of fructan in cold adapted genotypes of perennial ryegrass.
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