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Release studies revealed that hydrocarbon gel allowed highest drug release.
A general comparison of results for all the formulated transdermal films suggests highest drug release for the patches C1 and A1 formulated with K4CM and K15 M CR respectively (1.0%) in the presence of plasticizer PEG 400 (5% concentration).
During drug release study, SAN-1 showed the highest drug release followed by GMN-1.
The highest drug release was recorded in SAN-1 at 99.54%, while minimum drug release was found in GLN-3 at 73.54%.
It is clear that F2 matrix exhibited the highest drug release as 32.89% of IDM was released after 2 hours of dissolution test in pH 6.8.
The highest drug release occurred at 37°C in the most acidic buffer (pH 5.0), with approximately 14% of the loaded Dex released at the end of 14 days.
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It was clear that, formula (SSNEDDS-5) showed the highest drug released percent (99.9019% after 20 min) and according to ANOVA analysis, there was a substantial difference (P < 0.05) between the mean dissolution rates obtained from this formula, plain CC powder (12.5174% after 20 min) and marketed tablet (Atacand® 8 mg) (23.1033% after 20 min) in dissolution rate and extent (Fig. 5).
SS-SEDDS with Sylysia 350 fcp showed higher drug release and greater dissolution efficiency.
Capsule formulations of barrier coated-ADLP could achieve rapid dispersibility and high drug release.
These nanocomposites possess high heat-generating ability, pH and NIR responsive drug delivery, and heat-induced high drug release as well.
These nanocomposites possess high heat-generating ability, pH responsive drug delivery, and heat-induced high drug release as well.
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