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The highest dose was intended to restore physiological levels.
However, the effect of the highest dose was more evident the first year after planting.
The group fed on the highest dose was then fed with a HFG-free diet for a further 14 days.
A dose-dependent reduction of endothelial cell proliferation was observed after pegaptanib administration, while only the highest dose was able to inhibit fibroblast growth.
Among the three doses tested, the highest dose was the most potent and comparable with the standard drug bleomycin (0.3 mg/kg).
A reduction in the ratio DOPAC/OHTyr from placebo to the highest dose was observed, compatible with a shift in the dopamine metabolism to preferently produce OHTyr instead of DOPAC.
Similar(29)
The body regions receiving the highest dose were urinary bladder, kidneys and choroid plexuses.
Those who took the drug were given 20 milligrams of Cialis, the highest dose being studied.
The lack of long-term PFS, even at the highest doses, was disappointing.
(An even higher dose was originally submitted to the FDA, but it was withdrawn).
Higher dose was associated with improved local control.
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