There was no neuropathology up to the highest dose tested.
At the highest dose tested, 400mg, there was "marked suppression" of the hormones required for sperm production, she said.
However, AM251 increased the burying behavior in MBB at a highest dose tested (5 μg/mouse).
All vaccine constructs were protective from lethal challenge in mice, producing 93 100% protection at the highest dose tested.
The no-observed-adverse-effect-level (NOAEL) was 4000 mg/kg bw/day, the highest dose tested.
Given intraperitoneally, this extract inhibited carrageenan-induced rat paw oedema with IC50 of 102 mg kg−1, and with the highest dose tested (300 mg kg−1) producing 72.2 % inhibition.
Conclusion: MOTREM was found to be safe and well tolerated up to the highest dose tested (5mg/kg for a 15-min loading dose and 6 mg kg h for a 7.75-hours maintenance dose).
The consequence of ingesting Pf-5 bacteria was more severe; no larvae fed Pf-5 at the highest dose tested, 109 cfu/plate, pupariated (Fig. 2, Fig. S1).
Based on these data, a no-observed-adverse-effect-level (NOAEL) of 27.8 mg/kg/day, the highest dose tested, was identified.
Also, RGC-5 cells that do not express melanopsin were not affected by the UF008/SAP conjugate, even at the highest dose tested.
The highest dose tested of each lichen extract (10 mg lichen equivalent) was sufficient to reduce immunoreactivity below the threshold of detection.
