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The highest dose for each treatment series was determined based on the relative cell count (RCC) as a cytotoxicity index.
Therefore, we used a wide range of doses to ensure encompassing lowest dose for an observable effect, as well as the highest dose for maximal effect (Belz et al. 2007).
In contrast, the BMDL10 was lower than the highest dose for 694 data sets [the point estimate (BMD10) was lower than the highest dose for 546 data sets], and the NOAEL was lower than the highest dose for 596 data sets.
68 This resulted in dose-related reduction in insoluble brain Aβ that was significantly different from control groups at the highest dose for both Aβ40 and Aβ42.
The two lower doses in this study prompted greater change than the highest dose for auditory startle response, mating behavior, and body weight.
However, a more recent effort conducted by the ILSI Risk Science Institute has resulted in a consensus set of principles for dose selection, including selection of the highest dose for chronic rodent bioassays.
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The highest doses for gabapentin were 3600mg/day and for pregabalin 600 mg/day.
Hindpaw thermal sensitivity was significantly increased only at the highest doses for each drug.
Proteoglycan analysis of lumbar IVDs showed a decrease at the lowest doses but a significant increase at the highest doses for both males and females.
Pain inhibition at the highest doses for Og (113), MiL (108), Pg (84) and MiB (88) were comparable to that of paracetamol (97).
It is often reversible, but if a person has been on a high dose for a long time, it isn't," he says.
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