Increased doses of AS did not impact on clinical or pharmacodynamic outcomes in this setting of emerging artemisinin resistant malaria and were toxic at the highest cumulative dose evaluated.
Headache and fatigue were frequent with ombrabulin, and grade 3 thrombosis occurred at the highest ombrabulin single-agent dose evaluated (50 mg m−2), although none of these toxicities were dose-limiting with ombrabulin monotherapy.
dose had the most favourable toxicity profile of the higher dose levels evaluated, and data from the entire Phase I programme identify 400 mg b.i.d.
Interestingly, we did not see a particularly strong siRNA dose-dependent trend of GFP knockdown within the range of nanoparticle formulations tested, as almost all siRNA doses evaluated caused uniformly high knockdown.
The aim was to assess the onset of the anti-inflammatory action of low and high doses and evaluate the suitability of non-invasive assessments to demonstrate dose response.
In addition, the induction of apoptosis was confirmed morphologically by monitoring nuclear fragmentation after Hoechst staining and molecularly, at higher doses, by evaluating inter-nucleosomal cleavage and subsequent DNA laddering.
A total of 161 courses were administered to 63 patients (60 individual patients, three of whom were re-enrolled at a higher dose level and evaluated as new patients).
To determine the highest dose of atropine that can be well tolerated, 12 subjects, ages from 8 to 16 years old, were evaluated by Cooper et al.
End points evaluated include D 5cc) (minimum dose in Gy to 5 cm(3) of the esophagus receiving the highest dose), D 2cc), D 1cc), and D max) (maximum dose to 0.01 cm(3) ).
Escalating doses of bortezomib with high-dose melphalan was evaluated as as a conditioning regimen for autologous stem cell transplantation (ASCT) in patients with relapsed or refractory multiple myeloma (MM).
