In both plasma and urine, the higher dose allowed detection of a greater number of metabolites than the lower dose.
Retrospective analysis of the study of Honore et al. [ 12] suggests that a sufficiently high dose allows ~82% improvement in survival.
The rapid parasiticidal activity of artesunate at high doses allowed us to study the effects of the drug on the transcriptome of synchronized parasite cultures over a short 3 hour time window.
It hampered cisplatin-induced auditory brainstem responses threshold shift and higher doses allowed for complete morphological preservation of outer hair cells as proven by scanning electron microscopy examinations of the rat cochleae [ 24].
Administering higher doses allows one to treat patients with severe illness and/or organisms with high MICs.
Combined with the body of knowledge from allergen-SIT, these data suggest that initiating treatment with lower doses and building to the highest maintenance dose allows the full benefit of tolerance induction while also protecting the recipient from harmful side effects.
6 The two higher saxagliptin doses allowed a significantly greater number of patients to achieve the HbA1c target of <7% compared with placebo (38% and 41% versus 24%; P ≤ 0.05), and each saxagliptin group had significantly greater reductions in PPG-AUC in the 75 g OGTT (P ≤ 0.0002).
Thus, the highest EMS doses allowing good seed set and seed germination, 1.5% and 2%, were retained and tested on large batches of seeds.
Drug effects were dose-dependent but saturated at the highest doses, without allowing a complete recovery of TRR.
