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Gliomas are among the neoplasms with the highest degree of vascularization (19).
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Moreover, the heme profile indicated a higher degree of vascularization in gray matter.
The results showed that CoCl2 pre-treated BMSCs induced higher degree of vascularization and enhanced osteogenesis within the implants in both ectopic and orthotopic areas.
Despite its high degree of vascularization, a gradient of oxygenation is present in the bone marrow, and the endosteal surface of cortical bone appears to be among the most hypoxic areas in the body.
BAT differs from white fat by its high degree of vascularization and mitochondrial density.
In contrast to the high degree of vascularization and loose association with surrounding nonvascular tissue present in other barriers, the blood-labyrinth barrier is a sandwich of epithelial marginal cells and mesodermal basal cells interconnected by TJs.
Moreover, pharmacokinetic analysis of lipid-based delivery systems has revealed that, in the case of systemic administration, "first-pass" organs and those with a high degree of vascularization and blood flow (heart, lung, liver, spleen) exhibit significantly higher expression of the transfected molecule [2], [3], [6], [7] that is, consequently, cleared from the system very rapidly.
Histopathological examinations of the tumors generated from cRb−/−/RasV12 cells showed a high degree of vascularization (Figure 2E) and necrotic regions surrounding the tumoral core, caused by the chaotic cell growth observed in the tumoral morphology resembling to those observed in human GBMs.
They are associated with a high degree of vascularization and wound repair.
This may be explained by a higher degree of vascularization and a larger extracellular compartment in the active cellular tumour compared with dense immature fibrotic tissue.
VEGF is actively involved in the process of inflammation, osteoclastogenesis, and bone resorption [ 131– 133] and probably plays an important role in wear debris-induced inflammatory osteolysis since the periprosthetic tissues at the bone-implant interface show a high degree of vascularization [ 134].
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