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Also, we compared the results from Sorafenib's 8 targeted pathways, as compared to the 8 highest connected Immune System pathways.
One of these genes XLOC_099598 encoding a protein kinase ranked third within the DCG, making it one of the highest connected central genes in our network.
The 1500 highest connected genes in each of the lean, intermediate and obese sub-dataset resulted in a joint dataset of 3532 unique genes.
The A matrix was raised to the power 5. Based on the connectivity of individual SNP with all the other SNPs in the network, the top 1500 highest connected SNPs were selected for the network construction.
The top 12 (20% of total) of highest connected nodes included left superior frontal cortex, left lateral front-orbital gyrus, left precentral gyrus, left postcentral gyrus, left and right superior parietal lobule, left and right cingular gyrus, left and right angular gyrus, and left and right fusiform gyrus (Fig. 1 c).
The 14 most significant gene networks, each composed of 35 GATMs (nodes), are characterized by the presence of one hub gene (the highest connected node), which is the main player in the biological events that connect the GATMs.
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The presence of a couple of well-connected individuals (bigger red nodes) as well as a number of medium-high connected ones (orange mid-sized nodes) points out to the existence of some kind of hierarchic structure.
The presence of a couple of well-connected individuals (big red nodes) as well as a number of medium-high connected ones (orange mid-sized nodes) points out to some kind of hierarchic structure.
From this observation, we can infer that elastic closure of microfractures is important even in samples with high connected porosity.
The pore-dominated samples have high connected porosity and permeability, and lower permeability decrease in response to increasing confining pressure.
We also solve Swan's problem for the connected stable rank, in fact for an entire hierarchy of higher connected stable ranks that we introduce.
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