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Highest cell death activities were observed with novel dual-targeting tsRNAs programmed for trans-splicing toward AFP and a second HCC pre-mRNA biomarker.
Confirming previous studies, we found that hyperglycaemia and 3,4-DGE significantly increased both necrosis and apoptosis, with 3,4-DGE causing the highest cell death.
This latter finding may be related to the rapid degradation of 2-AG to arachidonic acid and glycerol in absence of MAGL inhibition, and the subsequent generation of prostaglandins, rather than PG-Gs, by the action of COX-1 and, to a smaller extent, COX-2, would would explain the highest cell death found after the combination of 2-AG and malonate compared with the cells exposed to malonate alone.
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PreA induced significantly higher cell death during the first two weeks.
The high cell death rate of FGCN-treated group was attributed to the higher nanoparticle internalization in cancer cells.
Peptide sequence with RNSCWSKD (TRAIL227 234) that exist in the zinc-binding site revealed high cell death inducible activity.
In comparison with RTA alone, MWCNT-RTA conjugates achieved three times higher cell death rates for L-929, HL7702, MCF-7, HeLa (75% mortality), and COS-7 cells.
The group treated with both PSi and NIR laser shows substantially higher cell death (necrosis + late apoptosis) rate than those not given both treatments.
Combination of PSi and NIR laser treatment techniques shows a substantially higher cell death rate than only one of these two techniques.
The maximum shear stress for inulinase production was about 0.22 Pa, since higher values cause higher cell death rates, affecting the enzyme production.
The highest spheroid density was obtained with perfusion, but overall the tissue construct displayed two distinct zones, one of rapid proliferation and one with almost no cell division and high cell death.
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