But what's striking is that though Crestor is more powerful than Lipitor, it is only slightly so at the highest approved dose.
In our study, upward dose adjustments for RA and the higher approved doses for AS and PsA (i.e., 5 mg/kg vs. 3 mg/kg for RA) could have contributed to higher medication costs for infliximab.
Objective To investigate the validity of recommendations in treatment guidelines to use higher than approved doses of oseltamivir in patients with severe influenza.
The high concentrations required, however, are unlikely to be reached in vivo using clinically approved doses.
High doses of GBCAs have been recognised as a risk factor in CKD patients [ 1], but even approved doses have been shown to be associated with occasional cases of CIN [ 22].
In addition, they resisted exposure to γ-irradiation at clinically approved doses.
Like the single-agent pazopanib dose-finding study, the tolerable dose is higher than the currently approved dose, chosen on the basis of PK parameters and analyses of biological activity (Hurwitz et al, 2009).
For example, Drake et al. described four case reports of adrenal insufficiency (presenting as hypoglycaemia) reported in children with asthma who had received high doses (500 1,500 μg/day; maximum approved dose in children under the age of 12 is 200 μg/day in most countries) of FP for 6 months or longer [ 21].
Based on the results of the phase II study CA184-022, where ipilimumab at 10 mg/kg produced greater tumor (radiographic) response rates (albeit with higher frequencies of irAEs) than the approved dose of 3 mg/kg, 52 clinical trials to further evaluate ipilimumab in melanoma and other tumor types utilize the investigational dose of 10 mg/kg.
The approved dose of palonosetron in Japan is threefold higher than the recommended dose in Western countries and was selected based on two dose-finding trials conducted in Japanese patients.
