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Results from the Attention Network Test indicated that caffeine enhanced both vigilance and the executive control of visual attention, but only at the highest administered dose (400 mg).
For the highest administered activity group in the current study, with an estimated absorbed dose to the bone marrow of 2.3 Gy, the WBC counts did not appear affected to any significant extent.
However, the activity distribution in the spleen and thymus was highly non-uniform; correspondingly, only the highest administered activity led to a significant reduction in spleen weight, and the thymus seemed to be insensitive to administered activity.
The highest administered molar dose of non-radiolabelled AF150(S) (approximately 50 nmol kg−1) resulted in a brain concentration of approximately 100 nM AF150(S) in vivo, a value that still lies 50% under the in vitro K d,H of AF150(S) (200 nM).
Although the peritoneal sensitivity to α radiation needs to be further studied before a tolerance dose can be estimated, it is likely that the highest administered activity concentration in the current study, which translates to 9 GBq in 1 L and 24 Gy to a human peritoneum, would be within a safe interval in a clinical situation.
Dose level 3 was identified as the highest administered DL.
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As an antibiotic, the highest recorded concentration of chloramphenicol in liver and in muscle suggest either higher administered doses or higher frequency of use.
The rationale for the higher administered dose of 99mTc maraciclatide for the 1-day protocol was to minimize the contribution of 99mTc sestamibi to the second scan.
We observed a tendency for lower antithrombin levels in the aPTT group, probably explained by increased consumption mediated by higher administered heparin dose.
The current study was designed to evaluate if higher administered activity concentrations of 213Bi-mAb could improve the therapeutic efficacy of 213Bi-RIT in an ovarian cancer mouse model.
Likewise, in the case of low-specific activity, i.e., a low nuclide to antibody ratio, of the 213Bi-mAb product, a high administered activity concentration could still lead to non-specific irradiation that could eradicate microtumors.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com