Sentence examples for highest activation of from inspiring English sources

The radiomimetic drug phleomycin induced the highest activation of NF-κB reporter activity in the p53 mutant SW480 cells, but only erlotinib induced NF-κB in both wild-type and p53-null HCT116 cells.

Finally, no cytokine production was observed after stimulation of γδ T cells with purified bacterial protein CagA (not shown), indicating that active processes mediated by H. pylori were required to achieve the highest activation of T cells and suggesting that CagA had to be actively translocated into the cells to exert its effect.

The highest activation of self-renewal might be anticipated during neutropenia following high-dose chemotherapy.

The highest activation of the GPER gene was observed with MF101 and NYA (Figure 5B), and E2, LIQ, DPN and ERB-041 for the SOX9 gene (Figure 5C).

However, in BJAB cells the highest activation of c-Jun was observed at the 0.5 uM concentration.

Similarly, medulloblastoma had the highest activation of EZH2 and lowest activation of HDAC4 in the GSK dataset but this was not completely replicated in the CCLE.

A high activation of caspases 3/7 activity and moderate activation of caspases 8 and 9 were also reported with the pterocarpan 39 as well as the xanthones 16 and 42 [ 18, 54, 55].

These results concur with Elk1 functional activity because we observed higher activation of this transcription factor in HT cells versus Karpas 422 cells after PGA1 stimulation (Fig. 3C).

The stronger and more persistent activity of PL supports a higher activation of CeA and a longer accumulation of DA released in NAcc.

The decrease in Akt activity by PI-3k results in a higher activation of transcription factors, such as FOXOs, which might lead to a higher transcription of E3 ligases involved in the muscle atrophy process [ 14].

Thus, our results suggest that while AL animals present high levels of eNOS activity only during the post-prandial period, DNP and CR animals maintain eNOS activity both when fasted and when fed, due to higher activation of Akt.