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The organs receiving the highest absorbed doses following administration of I-MIP-1095 I-MIP-1095 I-MIP-1095ds with areean absorbed dose of 3.8 mSv/MBq, followed by the liver with 1.7 msalivarynd the kidneys with 1.4 mSv/MBq.
The mean effective dose was more than 40% higher in female than male subjects, predominantly originating from the almost 60% higher absorbed dose to the urinary bladder wall and more than 90% higher absorbed dose to the kidneys in females.
For 211At, a higher absorbed dose generally resulted in a response involving a higher number of annotated genes.
High absorbed dose in humans was observed in the gallbladder (333 ± 251 μGy/MBq), liver (77.5 ± 14.5 μGy/MBq), small intestine (33.6 ± 30.7 μGy/MBq), upper large intestine (29.8 ± 15.0 μGy/MBq) and lower large intestine (25.2 ± 12.6 μGy/MBq).
Those with the PENTA dopant undergo a complex colour change since at lower doses blue colour formation is initiated but at higher absorbed doses a red colour appears that finally leads to a brown colour in the fibres.
Moreover, the relative long half-life of these radionuclides produces undesirable high absorbed doses.
In this study, large VOIs give slightly higher absorbed doses than the small VOI method.
Comparing the two age groups, the newborns showed 66% higher absorbed doses for the kidneys.
This could translate to high absorbed doses to the tumor using a β-emitter like 177Lu.
The response acquired at high absorbed doses cannot be extrapolated down to low absorbed doses or vice versa.
By the same token, areas of tumor receiving high absorbed doses can be spared superfluous secondary intervention.
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