The higher solubility of high-abundant proteins would work to prevent the aggregation of these proteins even if they become concentrated at specific sub-cytosolic locations.
On the other hand, though higher temperature causes higher reaction rates and higher solubility of substrate and products, yet oxygen solubility is usually decreased.
To ensure that the 500-nm peak assignment to monomer absorption is consistent, we have measured the spectrum of JC1 dye dissolved in methanol where (due to high solubility of the dye) its aggregation is inhibited and only the absorption band of dye monomers can be detected (peak at 517 nm in Figure 4c, dashed line).
The unbound fragments seem to determine the high solubility of the complex and hence, are favorable the protein aggregation protection.
However, this contradicts the high solubility of the whole NHBoc foldamer series in TCE.
Solubility is improved in hexane, chloroform, and DCM, with the highest solubility of all tested solvents seen in tetrahydrofuran (THF) [ 81 83].
Arginine has long been regarded as a suppressor of protein aggregation and can increase the solubility of aggregation-prone molecules [ 18- 21].
While preparing this manuscript for submission, Vendruscolo and co-workers proposed that abundant proteins are at a higher risk of aggregation and that their solubility must be maintained by the PQC system.
This property led high water solubility of PAMNPs and would overcome the aggregation of magnetic nanoparticles.
As an N-terminus fusion expression partner, RpoS increased significantly the solubility of many aggregation-prone heterologous proteins in E. coli cytoplasm, indicating that RpoS is a very effective solubility enhancer for the synthesis of many recombinant proteins.
The relatively high predicted solubility of medium- sized fungal hydrolases is in contrast to the low predicted solubility of small and large fungal hydrolases.
