Exact(3)
Regimens employing a higher single dose of rectal artesunate were five times as likely to result in >90% parasite reductions at 24 hours than were multiple lower doses of rectal artesunate or than a single administration of artemether.
In view of the fact that vitamin K has limited tissue reserves and is rapidly catabolised, with 60 70% of a single dose being excreted via the urine and bile in about 3 days, it seems reasonable that repeated doses rather than a higher single dose is more effective in preventing late VKDB [ 15].
However, our results showed that the DMFS rate only exhibited a statistically significant difference when the radiotherapy interruption time was >10 days, a result that is likely related to the higher total dose and higher single dose in the target area.
Similar(57)
Since no MTD was achieved, it is possible that higher single doses of RGD-A-TNF may also be safely administered.
The findings of CONFIRM-HF are thus compatible with those of FAIR-HF, but with patients followed to 1 year and using higher single doses (up to 1000 mg of iron).
Hypofractionated stereotactic radiotherapy (H-FSRT) is characterized by potentially lower toxicity than SRS, however, compared to FSRT, the risk for side effects seems increased due to the higher single doses (table 3).
9 This study showed that repeated treatment (up to eight cycles) with lower parenteral doses of B-arteether (5 10 mg/kg) was associated with brainstem damage after five cycles, whereas higher single doses (60 90 mg/kg) caused death without brainstem pathology.
The rationale for adopting the use of ferric carboxymaltose in our pediatric patients was to avoid poorly tolerated oral iron therapy and permit higher single doses of iron to be administered in shorter time periods with less overall numbers of infusions.
We have shown in previous studies that both fractionated irradiation and high single dose irradiation to the carotid arteries accelerate the development of atherosclerosis in apolipoprotein E-deficient (ApoE−/−) mice and predispose to the formation of an inflammatory, prothrombotic plaque phenotype [7], [8].
It is minimally toxic at a high single dose.
IORT implies delivery of a high, single dose of radiation to a limited intrasurgical anatomic area.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com