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By demonstrating how our predictions offer higher sensitivity than using global structure, and complement the use of sequence, we show that the presented ideas could advance the development of meta-servers in function prediction.
These imaging results show clearly that signals from Oct-4 targeting beacons and SSEA-1 stating using antibodies are highly correlated and therefore could be used in detecting cancer stem cells with higher sensitivity than using one marker only.
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Direct immunoassays using antibodies have an advantage of higher sensitivity than assays using Hb binding.
By combining bgaB and S-gal we achieved a much higher sensitivity than when using X-gal as a substrate as done by Suzuki et al. (2013).
Second, the methods used to identify the existence of spatial clusters might have higher sensitivity than those used to identify spatial clustering, at least as we used these methods in the study.
A strategy classifying all SR inconclusive tumours as malignant (SR+MA) yielded a significantly higher sensitivity (91%) than using the RMI (72%) (difference in sensitivity 0.19, 95% CI: 0.07 0.31).
The assay showed higher sensitivity than RT-PCR using T. gondii RNA as template.
CA242 was expressed independently of CEA, and the combination of CEA and CA242 gave in colo-rectal cancer considerably higher sensitivity than the use of only one of the markers.
Of note, the latter reporter protein in its secreted [24] or membrane-anchored [25] form should permit adjustment to novel experimental read-outs with the added advantage of displaying a higher sensitivity than other commonly used luciferases.
However in the Parham study cytological abnormalities were detected by monolayer liquid cytology, which is known to have a higher sensitivity than conventional cytology, used in our study.
Recent data indicate that promoter hypermethylation of the KIF1A and EDNRB genes is a frequent event in primary HNSCC and combining only the KIF1A and EDNRB genes provides a higher specificity and sensitivity than using a panel of 10 different genes (Demokan et al. 2010).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com