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We performed a systematic literature review, and where feasible, a metaanalysis, to evaluate whether women with SDB in pregnancy have a higher risk of specific adverse pregnancy outcomes compared with women without SDB.
We investigated HLA alleles that are correlated with a higher risk of specific autoimmune diseases, as we have previously shown that the appearance of autoantibodies and/or clinical signs of autoimmunity are strongly associated with improved RFS and OS in patients with melanoma who are receiving adjuvant therapy with high-dose IFNa2b.
The use of some specific medications might result in a higher risk of specific congenital anomalies, such as the anti-epileptic medication valproic acid, which results in an increased risk of spina bifida if used in the first trimester of pregnancy [ 3].
Increasing awareness among primary care providers about the higher risk of specific long-term complications in SLE, and improving care coordination by specialists caring for SLE patients through various practice innovations, such as automatic reminders in electronic medical records, may help improve the quality of preventive health care in this population.
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Neutropenia is defined by either an absolute or functional defect (acute myeloid leukemia or myelodysplastic syndrome) of polymorphonuclear neutrophils and is associated with high risk of specific complications that may require intensive care unit (ICU) admission.
A further set of biomarkers is represented by those able to identify patients at high risk of specific cancers.
Despite these factors, S100β concentrations could be an additional tool for the identification of patients at high risk of specific early neurological complications in clinical practice.
In particular, there must be interventions proven to improve outcomes for women and their babies who are screened to be at "high risk" of specific pregnancy complications.
50% of all subjects were considered to be at high risk of specific recidivism, i.e. they were classified as holding a high risk of repeating the index offence (cf. Table 1).
With the identification of highly penetrant genes that conferred an extremely high risk of specific cancers, it was generally considered that in such cases the contribution of genetic susceptibility would make environmental influences of little importance.
However, a wider group of people with high risk of specific CVDs could be targeted and treated earlier by increasing the sensitivity (by extending the time horizon to lifetime, as suggested by the Joint British Societies latest recommendations) and specificity (by using more specific diagnoses) of risk predictions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com