Exact(1)
While preparing this manuscript for submission, Vendruscolo and co-workers proposed that abundant proteins are at a higher risk of aggregation and that their solubility must be maintained by the PQC system.
Similar(59)
Taken together, our analyses indicate that in living cells, newly translated proteins presumably in a non-native form that exposes aggregation-prone sequences, are at a high risk of aggregation before they reach a stable native conformation.
Early familial aggregation and twin studies noted a higher risk of endometriosis among relatives.
Tricyclic antidepressants (TCAs), which decrease platelet activation and aggregation to some extent [ 3, 4], were associated with higher risk of MI [ 10, 11].
Central lesion location is associated with a higher risk of haemorrhage 31 and a potentially lethal outcome 28, as is failure to discontinue medication with platelet aggregation inhibitors 32.
Higher risk of death".
However, it is unclear whether the residual familial aggregation is due to rare mutations conferring a high risk of the disease, similar to BRCA1/2, or to common but lower risk variants.
High risk of bias (red).
High body fat = high risk of cancer.
Darius was at high risk of death.
On the other hand, high concentrations of kosmotropes strengthen hydrophobic interactions, increasing the risk of aggregation.
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