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The size and the number of plaques were slightly higher in L929 than in Vero cells, but this difference was strictly correlated with a higher replication of bacteria within the former (not shown).
Inhibition of the lysosomal activity by chloroquine treatment resulted in higher replication of bacteria in TAMs compared to that observed in control cells 24 h post-infection, indicating that TAMs kill bacteria by preventing their escape from the endosomal compartments, which progress into a highly degradative phagolysosome.
The existence of many rare QTL in the diverse founders sampled for NAM should minimise the effectiveness of joint-linkage analysis in this population compared with other possible mating designs that would provide higher replication of rare founder QTL.
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Indeed, the human brain consists of the order of 1011 neurons, but of the order of 100 1000 types http://neuromorpho.org meaning there is a very high replication of cells that are only different by their location and exact morphology.
The block design and the high replication of the Jena Experiment allow accounting for soil heterogeneity effects [18] and to delineate genuine diversity effects [10].
Thus, modulation of fatty acid catabolism could be detrimental to virus formation and could be a cellular mechanism to both produce energy and fight against a high replication of DENV-2.
We found that Ae. aegypti as well as Ae. albopictus ensured a high replication of the virus which underwent an efficient dissemination as detectable in the salivary glands at day 2 post-infection (pi).
In a previous study, it was demonstrated that high replication of Porcine circovirus 2 (PCV2) in a gnotobiotic pig was correlated with the absence of PCV2-neutralizing antibodies.
This may reflect the higher replication efficiency of H5N1 as seen in various cell lines (data not shown).
This polymerase lacks proof-reading capabilities which, when coupled with the high replication rate of the virus, results in the generation of a diverse population of viral variants or quasispecies (Simmonds, 2004).
Nonetheless, the high replication capacity of GFs should permit not only the generation of sufficient cells for iPS cell induction, but also the efficient generation of iPS cells from multiple expanded cell cultures.
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