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In general, the higher release rate, the higher impact on the water chemistry.
At the end of 48 h, the PLGA-PEG-NH2 NPs showed higher release rate of drug than PLGA NPs.
Compared to the coated samples, the uncoated samples show a higher release rate that decreases slightly with time.
The higher pH values lead to weaker hydrophobic force and hydrogen bonds, and thus higher release rate.
For example, SWSB-T80 demonstrated a higher release rate of 91% compared to the release rate of 58% from SWSB-T20 at the end of the experiment.
Despite the structural similarity between T20 and T80, the mechanisms of release are distinctively different, with the higher release rate observed in SWSB-T80 (~91%) compared to SWSB-T20 (~58%).
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Higher release rates in PBS than in sucrose media are attributable to the osmotic water flow from PBS into the donor phase, and subsequent increase in diffusivity.
Higher release rates were found after incubation bFGF-loaded fibers in cell culture media and with NIH3T3 cells than that in buffer solutions.
Slightly higher release rates can significantly increase the efficiency of a continuous release MLA strategy.
Commercially-available ALBC is guaranteed to be evenly blended, and has been shown to have higher release rates when compared to manually mixed cement [ 1].
Commercially prepared gentamicin-loaded acrylic beads are porous and show much higher release rates than hand-rolled, non-porous antibiotic-loaded acrylic beads (McLaren et al. 2004).
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Justyna Jupowicz-Kozak
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