Exact(2)
Non operative management is an appealing option in reason of the risk of physeal damage, however the recent literature uniformly indicates that conservative treatment of ACL tears in children results in a higher rate of instability that may progress to intra-articular damage, including meniscal tears (Fabricant et al. 2013; Henry et al. 2009; Ramsky et al. 2013).
Therefore, from the outset, the design of the experiments is not really appropriate for understanding the role of mtDNA mutations in leukemia since there is no way to know whether the differences observed between treated versus untreated patients were due to normal variation between individuals rather than a higher rate of instability in treated patients.
Similar(58)
Labral lesions are known to lead to higher rates of instability.
Both Cdx2- and BubR1-mutant mice exhibit a higher rate of genomic instability [35], [36], making them good models for prevention and treatment of colon cancers with chromosomal instability.
The higher rate of genomic instability and RER positivity in our study probably reflects the careful selection of a homogenous group of previously untreated CLL patients, meticulous selection of the tested loci and the use of very sensitive and specific modern method of Genescan Analysis for MSI detection.
The shoulder is the least constrained joint in the body, and is therefore susceptible to high rates of instability.
Higher levels of CENP-A in ER-negative tumors may reflect a higher rate of proliferation or chromosomal instability [ 35, 36] compared to ER-positive cancers.
Although African American women have lower rates of genuine stress incontinence than Hispanic and white women, they have higher rates of detrusor instability than all 3 groups.
RSCCs are generally diploid, and they exhibit higher rates of microsatellite instability (MSI) and higher expression of cytoplasmic c-erbB2 and epidermal growth factor receptors (EGFRs) [ 13].
In accordance with other reports, 6 higher rates of microsatellite instability were detected in MAC and SC than in AC in a subgroup analysis (P = 0.006).
Veterans were less likely to use MOVE!® if they were seen in VA medical centers with higher rates of home instability (OR = 1.09 95% CI: 1.02, 1.16) and lower rates of obesogenic psychiatric drug prescriptions (OR = 0.92, 95% CI: 0.90, 0.95).
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