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Our spatial analysis suggests that they could connect protected areas and have a higher rate of conservation management than terrestrial lands.
Our results presented in this study provide evidence that the miR-433 and miR-127 overlapping genes have a higher rate of conservation in mammalian species.
Lipman proposed that the higher rate of conservation of noncoding sequences of some genes is explained by the presence of antisense transcripts [18].
Nonetheless, binding intervals associated with annotated CRMs from FlyLight or REDFly display a higher rate of conservation than those located outside of CRMs altogether, which highlights their functional role.
Having observed that Dichaete binding shows a higher rate of conservation at functional sites such as known enhancers and core binding intervals, we asked whether a comparative approach could yield insights into the importance of common binding by Dichaete and SoxN.
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Likewise, maize is more closely related to sorghum than to rice; thus, sorghum pairs have higher rates of conservation in maize than do rice pairs.
This high percentage (more than 90%%) was indicative of a high rate of conservation among these strains [ 44].
The high rate of conservation observed between rice chromosomes 11 and 12 has also long been a source of speculation (Murat et al. 2010; Wang et al. 2011).
In wheat also, 39% of EST-SSR markers detected multiple loci [ 38], which is probably due to the high rate of conservation of EST-SSRs across the three genomes of this species, as well as 25 30% gene duplication [ 42].
Not surprisingly, we did not detect a higher rate of nucleotide conservation in intervals showing four-way binding conservation compared to the unique D. melanogaster intervals; in fact, the uniquely-bound intervals show slightly, but significantly, greater sequence conservation across their entire lengths (Wilcoxon rank sum test, p = 2.34e-20).
Interestingly, Myc20 displays a higher rate of residue conservation compared with Myc17, pointing to differences in post-transcriptional regulation and, subsequently, different protein stability rates between the two medaka orthologs.
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