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We present here the activity data showing a very interesting response rate of 59.5%7%7% complete response) that is at the higher range of activity previously reported for this disease.
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A more robust pre-clinical wear simulation framework is required in order to simulate wider and higher ranges of activities, observed in different patient populations such as younger more active patients.
A strength of this study is the sample of 31 022 adolescents collected in the Nordic countries, ensuring good coverage even in the higher range of screen-based activity.
This fact can be explained further by comparing the performance of the two methods across activities that involves higher range of pelvic motion therefore more prone to soft tissue artefact.
Pl1 showed a broader range of activity with higher specific activities against short to medium acyl chain length: the activities were respectively 247.8 U/mg with ρ-nitrophenyl butyrate, 317.5 U/mg with ρ-nitrophenyl caprylate and 224.6 U/mg with ρ-nitrophenyl caprate and laurate.
We screened these same isolates for C8-HSL production using a fluorescent reporter strain and observed a range of activity from high (B. cepacia ATCC25416, B. cenocepacia AU1054, and B. ambifaria AMMD) to low (B. multivorans ATCC17616), but these values also did not correlate well with nematode preference (Table 2).
The activity of bfAANATs towards the substrates tested (10 mM) was relatively similar and fell within a 5-fold range of activity; the highest activity was observed with PEA, however, bfAANATα and bfAANATδ' seemed to show a slight preference for hydrophobic or polar substrates, respectively.
Activity covered an 18-fold range, which was generally higher than that seen in cell lines but within the range of activity measured in the transfected clones.
The range of activity scores is from 0 (lowest participation) to 7 (highest participation).
Applied on a population with low PAL (patients with chronic obstructive pulmonary disease), the ActiReg is found to be a valid tool to assess energy expenditure and distinguish between both the low intensity activity range and moderate to high intensity activity range of physical activity [ 36].
The functional interference of pain is also high, and a whole range of activities are often severely curtailed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com