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In addition, compounds 8a and 9b f demonstrated higher potencies than Vemurafenib against A375P.
Of the dipyridamole analogs evaluated, about one fourth of the compounds inhibited hENT4 with higher potencies than dipyridamole.
In the ?-arrestin-2 patested all tested compounds had higher potencies than DA (pEC50 of 6.97) with NPA being the most potent (pEC50 of 9.67).
A focused library of 20 compounds was designed and synthesized, among which eight compounds showed equivalent or higher potencies against HDAC1 as compared to vorinostat.
In vitro antitumor activity assays in HCT-116, PC-3 and HL-60 cancer cells revealed six compounds with potent antitumor activities, and compound 1o showed 6- to 9-fold higher potencies compared to vorinostat.
The efficiency of CD4-specific CB1-inserted PIN-bodies was confirmed in biological assays where these constructs showed higher potencies to block antigen presentation by inhibition of IL-2 secretion and to inhibit the one-way and two-way mixed lymphocyte reactions, compared with soluble anti-CD4 PDP CB1.
Similar(34)
Most of the conjugates displayed higher potency than their components.
The compounds generally displayed higher potency than amonafide.
Smaller PEG chains were similarly associated with higher potency.
This shows higher potency of MCPs compared to the ZnO NPs alone.
Higher potency was also observed for 26 (3.7-fold) in comparison with M6G.
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