These features are incorporated in a discriminative classifier, which approximates the higher order potentials during the inference procedure.
Most SEP-based methods use pairwise potentials (Bahar and Jernigan, 1997; Samudrala and Moult, 1998; Sippl, 1995), though some studies have employed higher order potentials; for example Vaisman et al. (1998) used a four-body potential.
PaMpl is present as a monomer in the crystal asymmetric unit and crystal packing analysis using PISA [41] did not identify any potential higher order oligomers in the crystal lattice.
Similar interactions were also observed in the present analyses using the CHAMBER approach, although additional potential higher order effects were detect by CHAMBER that were not seen in our earlier work (no prior multigene analyses of endometrial cancer have been undertaken).
New endeavors must be undertaken to address potential higher order interactions existing among genes in view of revealing underlying common mechanisms in more complex diseases.
Potential higher order factor solutions were examined using exploratory methods to examine whether the eight factors represent different constructs or whether they reflect different facets of multiple higher order concepts.
Because the number of potential interactions grows exponentially with the number of variants being examined, it is not computationally feasible to evaluate every potential higher order interaction in high-dimensional data.
To study potential higher order structures of our TRNs, we collected all the instances of CM and TS motifs and traced the structural organization of the CM part (i.e. the part formed by all the instances of CM motifs) and the TS part (all the instances of TS motifs) in every TRN Since there are no TS motifs in the liver TRN, we started the study with the TRNs of the other seven tissues.
Physical properties as thermal expansion, heat capacity and Grüneisen parameter can be explained with higher order terms of the interaction potential.
Further work to build a theoretical model incorporating higher order perturbative terms in the potential in order to predict the confinement time scaling with B, would help in designing traps that can minimize these perturbative terms [36, 37].
