Your English writing platform
Discover LudwigExact(7)
Firstly, calculating the threshold of the PWM based on the scoring range of the model it is clear that including a higher order background model will effectively lead to an altered scoring range and thus affect the absolute threshold value.
In fact only the poorly performing statistics seems to borrow strength from the higher order background, while the better performing statistics are hurt by the increase in background model.
Often there is too little information in the original alignments to estimate anything but a zeroth order model for the transcription factor binding site, however it can be combined with a higher order background model to take into account dependencies in the nucleotide composition.
We have verified that higher order background models did not change the predictions significantly.
Similar approaches have been used for prediction of mRNA cleavage in yeast [ 14] and C. elegans[ 15], with more complex models of the polyadenylation region including 4 to 6 distinct subsequent signal regions interspersed with higher order background models.
This creates a problem: instances of an abelian pattern do not necessarily have the same expectation under a higher order background model and, hence, the described algorithm would not be applicable.
Similar(53)
To further deal with phase errors (or terracing) common in FCT type methods, high order background dissipation is added to the antidiffusive correction.
The use of variational gradient recovery makes it possible to add high-order background dissipation leading to improved approximation properties in smooth regions.
Several authors have reported that the use of higher-order background models improves motif discovery [67], [69].
By conditioning score functions on the terminal residue j associated with a score pair (si,s'i), the convolution also accommodates higher-order background models (10).
Higher-order background information (e.g. tri-nucleotide, tetra-nucleotide) can be considered in the future for model improvement.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com