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In addition, a reiterative process of PWM optimization and selection of rationally informed cut-offs based on newly discovered and validated sRNAs may allow for progressively higher levels of specificity without excessive loss of sensitivity.
10, 11 We found that a number of sign and symptom combinations could provide higher levels of specificity for cholera surveillance in Haiti.
23 The Malawian study found considerably lower sensitivity for women's reports of being in a relationship, where an age disparity greater than 5 years was only 24.3%, compared to 79.6% here, but similar or higher levels of specificity.
While there was no clear difference at higher levels of specificity, the ROC curves for right- and left-sided advanced neoplasia diverged (towards higher sensitivities for left-sided advanced neoplasia) starting at a specificity of about 87%, which corresponds with a cutoff level of 2 μg haemoglobin per g stool.
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Grid analysis provides a higher level of specificity to weather patterns compared to the broad, low precision county level analysis previously conducted by multiple governmental and state agencies (e.g. FEMA 2002, 2008; NCDC 2013).
This newly emerging strategy, which is thought to yield a higher level of specificity than conventional ATP analog inhibitors, may lead to the development of a different class of inhibitors that could be used either alone or in combination with available catalytic inhibitors to achieve increased drug efficacy.
In the same vein, while intersections of computational approaches may achieve a higher level of specificity, they also generally achieve a much reduced sensitivity [32].
Here we introduce a new more highly validated allelic discrimination assay, referred to as BurkDiff, to provide a higher level of specificity for accurate identification of B. pseudomallei and B. mallei and simultaneous differentiation when necessary.
On the other hand, RNA - DNA interaction provides much higher level of specificity and better way of gene expression control.
Blocking or competitive ELISAs have been shown to be especially useful where a higher level of specificity is required.
In order to address this, we moved our comparisons further along the ontology to provide a higher level of specificity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com