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Thus, temporal deregulation of the Mus81-Mms4 pathway via constitutive Mms4 phosphorylation induces higher levels of deleterious crossover and precocious processing of DDT- and replication-associated SCJs.
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If cold-adapted populations generally harbor higher levels of synthetically deleterious alleles that are masked at cold temperatures and revealed at warm temperatures, this may explain the commonly observed asymmetric patterns of fitness effects between cold- and warm-adapted populations in common-garden experiments.
In addition, both first- and second-line anti-TB drugs are available without prescription, which encourages self-treatment and the uncontrolled use of these drugs may contribute to higher levels of resistance, with a consequent deleterious impact on treatment success [ 21, 22].
Although not as strong a finding, patients with stage I cancer also showed poorer survival with higher levels of AGR2, which could suggest a deleterious role for AGR2 in lung cancer.
This is apparent in the plots of Ks against both Ka and K16S, in which those bacteria subject to higher levels of drift have elevated divergence at slightly deleterious sites (Ka and K16S) relative to neutral sites (Ks).
Alternatively, higher levels of SM species may be compensating for the deleterious increase in TG with age in females.
Thus, in this simple arithmetic task, the reduction of internal working memory capacity through articulatory suppression had its most deleterious effect on participants with higher levels of math anxiety.
Higher levels of IL-10 and IL-22 in PMX-HP group may suggest unexpected deleterious interference between these cytokines and polymyxin-B membrane.
Higher levels of interleukin-10 and interleukin-22 in polymyxin-B hemoperfusion group may suggest unexpected deleterious interference between these cytokines and PMX membrane.
Furthermore, the model predicts higher levels of neutral diversity in pericentromeric regions, which harbor a lower density of sites subject to deleterious mutations.
Higher levels of carbon dioxide.
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