Sentence examples for higher level upstream from inspiring English sources

RCR integrates large-scale transcriptomic data into biological meaning by identifying higher level upstream controllers of specific gene expression.

RCR 24 is a knowledge-driven approach used to identify high-level upstream controllers, HYPs, which could explain the observed differential gene expression profiles.

27 The RCR method 24 integrates large-scale transcriptomics data into a biological context using information from differentially expressed genes together with a priori knowledge of cause and effect relationships to identify high-level upstream controllers of the observed gene expression called hypotheses (HYPs) (for details, see Refs. 25– 25).

Because software often has the last word in generating a result, then, it demands an even higher level of trust than upstream inputs.

Afterwards, elements are "upgraded" to the next higher level if they have no upstream elements and if they are positioned at the same layer as one of their targets.

Over regions detected with both modifications, H3K4me3 and H3K27me3 showed a slightly higher level particularly over the 5 kb upstream of the TSS, relative to on "-only" regions, suggesting that H3K4me3 and H3K27me3 co-enriched promoters harbor a distinct chromatin configuration.

Due to the "upstream" (i.e., higher level and affected by fewer factors) and inclusive nature of the exposure, we identified few potential confounders for inclusion in the county-level models.

As shown in Figure 2F, this key upstream regulator of autophagy showed a significant higher level in the PBMC obtained from HIV-1 controllers with respect to HD.

For example, the higher level activities of URSs Pcec [ 50] and Mac [ 51] were constructed by introducing enhancer motifs into the upstream of native constitutive URSs.

In general, fast action is made by the enzyme level regulation such as the feed-forward activation of pyruvate kinase (Pyk) by fructose 1,6-bisphosphate (FBP), and the feedback inhibition of phosphofruct kinase (Pfk) by phosphoenol pyruvate (PEP), a motif that enables a high level of the upstream metabolite to lower the level of the downstream metabolite [117] (Figure 3a).

In the case of high-usage and low-usage distal polyA sites, the results showed that the varying tendencies of upstream and downstream nucleosome occupancy were the same, though the change in the upstream nucleosome level was smaller than that in the downstream nucleosome level (upstream nucleosome p < 1 × 10-3, downucleosomecleosome p < 1 × 10-19; Figure  4E).