Procedures using the GO database [ 40] and perl API [ 41] were developed to classify specific GO terms into general categories described by higher level terms.
The full GO contains thousands of specific terms while the GO Slim is a reduced set of broader higher level terms that is easier to represent graphically.
The TAO is based on the Zebrafish Anatomy Ontology (ZFA) (from the ZFIN database, Bradford et al., 2011), and uses general (higher level) terms from the Common Anatomy Reference Ontology CAROO) (Haendel et al., 2008).
The controlled vocabularies have a hierarchical structure, higher level terms being more general than lower level descriptors, allowing annotation to be performed to an appropriate level of granularity whilst also enabling search tools to return all mapped objects to both parent and child terms, if required.
analyze a full matrix of gene gene pairwise similarities from -omics data; infer true hierarchical structure in these data rather than enforcing hierarchy as a computational artifact; and respect biological pleiotropy, by which a term in the hierarchy can relate to multiple higher level terms.
That is, querying for all 'elongate' jaws, for example, would return jaws of all shapes because all descriptions of jaw shape variation are annotated to the high level term shape.
2) High level term is a first grouping level.
AE = adverse event; ALT = alanine aminotransferase; AST = aspartate aminotransferase; ULN = upper limit of normal a p values are from Fisher's exact test AEs are reported by MedDRA High Level Term.
Adverse events occurring during this study will be presented by system organ class (SOC), high level term (HLT), and preferred term [ 65] in a frequency table giving the number of events, number of subjects, and percentage of subjects who experienced the event by treatment group.
There was a tendency for many men to talk about their needs in very abstract or high level terms (e.g., "I need more money," "I need a new job," "I need a girlfriend," etc).
Only 31.3% of PTs are grouped in high level terms classes (HLT).
