For our experiments, we required a high level specificity of detection to discriminate among miRNAs derived from the parasite, mammalian and intermediate freshwater molluscan host.
This higher-level specificity strongly suggests that coevolution between termites and fungi, has occurred.
Grid analysis provides a higher level of specificity to weather patterns compared to the broad, low precision county level analysis previously conducted by multiple governmental and state agencies (e.g. FEMA 2002, 2008; NCDC 2013).
In the same vein, while intersections of computational approaches may achieve a higher level of specificity, they also generally achieve a much reduced sensitivity [32].
Here we introduce a new more highly validated allelic discrimination assay, referred to as BurkDiff, to provide a higher level of specificity for accurate identification of B. pseudomallei and B. mallei and simultaneous differentiation when necessary.
Blocking or competitive ELISAs have been shown to be especially useful where a higher level of specificity is required.
On the other hand, RNA - DNA interaction provides much higher level of specificity and better way of gene expression control.
In order to address this, we moved our comparisons further along the ontology to provide a higher level of specificity.
In this example it can be seen in Fig. 3 that, for very low levels of sensitivity, lactate has a higher level of specificity than urea.
This remains an attractive therapeutic approach because it offers a higher level of specificity and decreases many associated toxicities found with conventional cytotoxic chemotherapy.
In addition, a reiterative process of PWM optimization and selection of rationally informed cut-offs based on newly discovered and validated sRNAs may allow for progressively higher levels of specificity without excessive loss of sensitivity.
